# 4    Sources of Chronic Inflammatory Elevation and Actions to End

Please note that all of these trigger the NFkB gene activation and subsequent production of inflammatory cytokines. All physiological insults to body trigger this mechanism. Many pathogens have also learned to use the inflammatory process to aid their survival and further multiplication.

Heavy metal contamination It is widely understood in science that toxic heavy metals lead to activation of NFkB activation and production of inflammatory cytokines that can produce a chronic inflammation problem.You must get rid of these by detoxification, if you have silver filings, you have slowly leached out mercury (Hg) that is extremely toxic and thereby inflammatory. Toxic heavy metals lead to the activation of NFkB production of inflammatory cytokines. Toxic heavy metals should best be removed by two diet components that trap these in the gut tube and are evacuated as feces. This lowers the burden on the kidneys. See DETOXIFICATION OF HEAVY METALS & ORGANICS PDF for SUBSCRIBERS.
Organic molecules/drug contamination Abundant evidence indicates that enviromental poisons (toxic heavy metals, many organic chemicals, etc.) cause epigenetic changes that parallel the epigenetic changes in our various age-associated diseases, Epigenetic change is changes from normal tissue proteins expressed to another often pathological pattern, without damage to the DNA itself. in general epigenetic changes are always associated and likely caused by chronic inflammatory conditions. You must get rid of these by detoxification with binding structures and body's own oxidation-coupling to glutathione for voiding. The safest way to remove these persistent toxic organic molecules is via a slow process through the kidney, but this takes time to avoid injuring the kidneys. See
Gingivitis (bacterial inflammation of gums) by inflammatory bacterial lipopolysaccharides Bacterial inflammation of the gums also results in release of bacterial lipopolysaccharides and other and inflammatory molecules. Absorption of these into the blood to travel the whole body leads to higher whole body inflammation and often severe cardiovascular disease consequences. To end the bacterial gingivitis, see Tooth Care under the Externals Section of LHL.net.
Oxidation of LDL in the Arteriosclerosis process The need for powerful long lasting protective antioxidants cannot be over stated here. The whole process of inflaming the blood vessels and heart leads to yet further whole body inflammation and damage. Long lasting antioxidants are covered in the
Elevated blood glucose levels Elevated glucose levels aggravate multiple sources of inflammation. Lower blood sugar levels by improving insulin function to clear excess glucose from blood and also avoid intake of readily available carbohydrates (or any carbohydrates). This especially includes simple sugars. The How and Why Section has a
Read More section to Improve Insulin Sensitivity which will greatly lower blood glucose levels. For more advanced cases (eg. Type-2-Diabetes) there is the Type2Diabetes-LiveNornalAgain.PDF for SUBSCRIBERS. Type-2-diabetics usually are not told that even perfect glucose maintenance will not prevent, only delay the worsening of this very inflammatory disease that drastically causes organ misdirection in 8 separate organ systems. Eating a diet extremely low in AGE's is an absolute requirement. This is where cooking foods is greatly accelerating the negative consequence of T2D.
Dietary intake of AGE & ALE components AGE's & ALE's
(Advanced Glycation/Lipid End Products) are cooking heat caused cross linked components made of two or more of proteins, lipids, and carbohydrates. Our body has no enzymatic ways to correct these profoundly inflammation causing molecules. Note that AGE come from both cooked foods in our diet or those we internally form from our blood sugars reacting with proteins and lipids. These AGE's & ALE's are able to engage the vascular RAGE receptor. This receptor is then activated to alert passing lymphocytes to produce inflammatory cytokines. This is a secondary mechanism of triggering a systemic inflammatory bacterial alert (besides the macrophage presentation of samples of a foreign invader that alerts our body to the probable presence of a bacterial infection). This AGE & ALE misdirection can produce a very large inflammatory response that continues every day we eat cooked foods that trigger this response. To solve this, we can start by eating our vegetables and fruits raw, and cook to no higher than the boiling point of water (212oF or 100oC). Eating uncooked safe foods like yogurt (dairy and oat) or sprouted beans eliminate the cooking requirement. Much more details in the subsection READ More for AGE's and ALE's. Ways to get rid of both AGE and ALE as well as the long term garbage collected in our cells called 'lipofuscin' are in the AGE&ALE & LIPOFUSCIN REMOVAL.PDF for SUBSCRIBERS. Lipofuscin is a complex cross linked mess of discarded mitochondria hulks and other proteins and lipids. Nerve cells in our 'memory routing' hippocampus can accumulate 50% of cell volume as this lipofuscin. When this is removed by the technique described in the PDF, the cell has a nerve firing rate of a younger cell. This process may account for much of our brain decay, and it can be reversed safely !
Excessive belly fat that 'stuffs' our fat cells inside the gut. These stuffed fat cells become distressed and signal that to nearby macrophages. Both cells then produce inflammatory signals (mainly inflammatory cytokines) that go systematic (all over the body). When systematic, they can trigger further inflammatory cytokine production. This is part of the problem of a big belly. You are setting your self up for an onslaught of inflammatory acceleration of various age-associated diseases. See the
WEIGHT REDUCTION AND LEAN MAINTENANCE PDF for SUBSCRIBERS. With the right diet and supplements you are not hungry and drop weight in a healthy way - while learning to exercise & eat foods that maintain stable weight.
Unfavorable balance of bad to good (beneficial) bacteria in the colon The large intestine 'colon' is where over 90% of the some @ 10^14 bacteria that live on us or in our gut tube are located. This is ten fold greater than the number of cells in a human being (@ 10^13). By the time food gets to the colon, almost all protective antioxidants are already absorbed. What protection that is left consists of proanthocyanidins (circular chains of covalently linked flavonoids that are too large to absorb) and compounds like phytates (a six member carbon ring of that can have up to six phosphates attached). A great secret of the colon is that beneficial bacterial can eat some of plant oligo-fructose compounds (humans can't digest them) that the bad (dangerous, inflammatory,& pathogenic to us) bacteria mostly cannot use.  In this way beneficial bacteria can out compete them and out reproduce them. The result is a shift in numbers toward higher beneficial bacteria to pathogenic one. This means less inflammation as well as the production of butyrate (a 4 carbon saturated fatty acid found in milk, cream, and butter). Butyrate is a compound that feeds our colon cells and also reverts abnormal cells to normal or leads to their death. Since we usually don't eat enough of these soluble plant fibers, colon cancer is undergoing a massive rise in our country. Different cancer types  (stomach, colon, prostate, and many others) rise or fall with changes in our diet. Many of the changes of our diet have been very bad. Once you understand what to do and what not to, you are greatly protected. See the
Highly oxidant conditions in the body   Insufficient sources of antioxidant intake and/or a pathological high level of free radical production will tip our system to high inflammation status. This can be largely offset with higher levels of both supplemental antioxidants and increased production of you own body made antioxidants. See the Antioxidant & Supplement Sections of LHL.
Auto-immune Reactions   Autoimmune diseases are a aberrant immunological attack response to our own body. Suppressing this is important, because autoimmune diseases often lead to yet further reactions to different normal proteins in an expanding nightmare. Autoimmune reactions very often lead to high levels of free radical damage to bystander cells that produce more inflammatory cytokines that generate chronic systematic elevation of overall inflammation. There are many ways to lower the levels of autoimmune reactions, one of which requires a specific good gut bacteria to help this process. This gut bacteria suppresses abnormal immune responses and modulates the over all immune system in a cooperative way in mammals. The suppression of bad auto-immune reactions caused by this beneficial bacteria may be the reason why autoimmune diseases wax and wane - all you need is to fail to support this bacteria and its suppression is lost. See the
Acute or Chronic Bacterial Infection  Bacterial infections not only produce lipopolysaccaharides that are 'direct' 'high level' inflammation causing substances, but some chronic infecting intracellular bacteria (mycoplasmas) turn on the inflammatory process in our cells to defend themselves and also to benefit from the problems caused by this. A strong immune system and dealing with the very common place mycoplasma bacteria is critical to avoid unwanted rises in whole body inflammation. All diseases are intrinsically disease elevating (encourage further diseases). This is covered in the IMMUNE ENHANCEMENT PDF
Acute or Chronic Viral Infection Viruses that only are 'alive' when they infect a living cell. They can cause profound inflammatory elevations. Many viral infections are long term chronic disasters that massively raise inflammatory events and even trigger cancers and organ degradation. A robust response from our (AUGMENTED if need) immune system is required to eliminate both acute and chronic viral infections (if possible). Immune system enhancement is covered in the IMMUNE ENHANCEMENT PDF
Acute or Chronic fungal infection Fungi are also dangerous smart players in this game of either blocking our immune system from eliminating them and often turning our own intracellular inflammatory defense system on for their benefit. A robust response from our (AUGMENTED if need) immune system is required to eliminate both acute and chronic fungal infections. Immune system enhancement is covered in the IMMUNE ENHANCEMENT PDF
Acute or Chronic Protist infection Protists are eucaryotic single cells, which means they have internal mitochondria and a membrane bound nucleus like our cells. Some protists are very toxic to us and can rapidly kill or sicken us unless recognized and treated. Please realize that LHL is not against needed medicine, only against stupid and exploitative medicine.
Larger Parasites (Worms, etc.)  Large parasites can often overcome our immune system by being large enough to limit the damage our immune system inflicts on much smaller critters. Sometimes this 'escape from our immune system attack' is so perfected that we need to use rather dangerous drugs targeted at these parasites. Experts estimate that over one tenth of the US population is infected with pin worms, so this is not a hypothetical concern. Worms usually impair our energy, our mental drive, and make us more susceptible to other infections from bacteria and viruses. One of the options covered in the IMMUNE ENHANCEMENT PDF
for SUBSCRIBERS is functional as a treatment.  Alternatively, medical drugs (despite toxicity) and natural remedies are also suitable.
Misfolded Proteins A habitual misfolding of a otherwise normal protein structure can elicit a free radical response, and then generate an inflammatory immune reaction. A whole class of pathogens that are protein (not DNA based) are called 'prion' proteins. Basically, these aberrant proteins act as templates to cause a misfolding of their target protein. This misfolding continues and forms toxic aggregates called amyloid plaques that are injurious to cells as well as elevating inflammation. These 'protein' pathogens are not killed by cooking, nor subject to any other medical techniques. We must learn to avoid ingesting them, no other solution works here ! More details at Prions (COMING SOON)on LHL.
Radiation Exposure    Exposure to external or internal radioactive material activates the usual NFkB 'central master switch' of body inflammation. This is best avoided. Unfortunately, Fukushima has and is delivering growing levels of radioactive Cesium (Cs137) (gamma emitter) and Iodine (I 131 beta electron emitter) as well as potentially more Plutonium (Pt139) and alpha emitter). Fortunately we have not yet seen high levels of Strontium (Sr 90) which stays in our bones for a lifetime.

The body senses “danger” from “damaged self” molecules through members of the same receptor superfamily it uses for microbial “non-self”, triggering canonical signaling pathways that lead to the generation of acute inflammatory responses. For this reason, the biology of normal tissue responses to moderate and clinically relevant doses of radiation is inextricably connected to innate immunity... Although this is an oversimplification, it is certainly true that the pathways are restricted and the target genes for NF-kB and AP-1 activation are pro-inflammatory cytokines...    Links between Innate Immunity and Normal Tissue Radiobiology  Dörthe Schaue and William H. McBride  Radiat Res. 2010 Apr;173(4):406-17.   

Smoking - Smoking damage like other physiological insults is found to be mediated by NFkB activation. NFkB is the 'master switch' for inflammation and leads in these pathological cases to high levels of inflammatory cytokines that accelerate age-associated diseases., This  NFkB activation by pathological physiological insults is likely also the master switch for the process of epigenetic (changes in expression, not damage to DNA) that can directly lead to a pre-cancer and then cancer, as well as other age-associated diseases. Which one is likely dependent on genetics and environmental exposures over the life time.

Smoking is reported to effect a number of biological mediators of inflammation through its effect on immune-inflammatory cells, leading to an immunosuppressant state. Recent evidence strongly suggests that the molecular mechanisms behind the modulation of inflammation by smoking mainly involve the nuclear factor-kappa B (NF-kB) family...   Impact of smoking on inflammation: overview of molecular mechanisms.  Gonçalves RB, Coletta RD, Silvério KG, Benevides L, Casati MZ, da Silva JS, Nociti FH Jr.  Inflamm Res. 2011 May;60(5):409-24.