Longer Healthy Life
HOW & WHY
© Copyright 2011 Ty Parr, Ph.D.(All Rights Reserved) Updated 30Apr2011
The riddle of a Longer Healthy Life is exemplified in the Japanese Sacred Knot of Longevity (Nade-Takara-Nusubi) that appears flanking the title of this site. This is a continuous interwoven, interconnected knot without ends that represents the complexity needed to assure longevity (a Longer Healthy Life). This represents an interacting complexity of wise judgments. One must act in a way to do the correct things and avoid needless damaging things. While this sounds simple, it is not. We will detail in this section what (literally the 'How & Why') science has established as beneficial for a Longer Healthy Life and highlight those other actions that rob us of this prize. This will not be some monastic isolation nonsense, but things you can put in practice immediately. What you will find is that you are aging slower than the others around you and you will retain your physical and mental strength. This puzzle can also be compared to the attaining different levels of protection and understanding that "progressively" lengthen your Longer Healthy Life with each further Level. We will refer to these successive steps as Level 1, Level 2, etc.
Please note that there are TWO LEVELS 1& 2, with LEVEL 1 the First 3 steps (1, 2, & 3) should all be done together to postpone problems so we get some time for LEVEL 2 steps (4 to 9) to fix the underlying problems. SUBSCRIBERS WILL GET FURTHER LEVELS.
SUCCESSIVELY ACCOMPLISHED DUAL LEVELS (Level 1 & Level 2) OF IMPROVING OUR LONGEVITY
LEVEL 1 ( steps 1,2,3) - get control of glucose handing & lower inflammation, cut down AGE intake, Exercise, ingest long lived Antioxidants to suppress damage and use Adaptogens to optimize body metabolic status (prevents catastrophic worsening!)
1. Improve Insulin Sensitivity and Glucose Handling & Lower Rising Chronic Inflammation ( READ this free InflammationINFO&Cocoa/Yogurt Drink PDF first)
We are doing this before addressing the underlying causes because it buys us time. Steps 1 to 3 are so crucial that the later steps will do almost no good if these problems are not postponed. See below Read More... for more detail and a table of how to improve Insulin sensitivity and read and do the free InflammationINFO&Cocoa/Yogurt Drink PDF to lower inflammation. Steps 1 to 3 are critical in delaying the acceleration of age-associated diseases by these very negative processes. There is no point in later steps if these are not done. These two processes (increasing insulin sensitivity and lowering inflammation) are what has been found in the oldest humans (centenarians - living over 100 years) and in long lived Calorie Restricted animals. Read MORE about increasing insulin sensitivity.2. Alter Diet to Lower Dietary Ingestion of Cooking AGE's - When any two or more of proteins, lipids, and carbohydrates are heated, they form abnormal cross linked molecules called AGE's (Advanced Glycation End Products). Our body does not have enzymatic means to get rid of these AGE's. Cooking caused AGE's and ALE's are a major (if not the major) cause of elevated chronic inflammation in otherwise healthy trim humans. This has a profound negative effect on life spans. We know this from an experiment on rodents where Calorie Restriction leads to a 20-30% increase in maximal life span over freely feeding controls. When the CR animal's food was heated 15 minutes. at 120°C (248°F) this extension of life span was completely removed in spite of still being CR. Thus, the benefits of CR are completely abrogated by just heating the food for a short period of time. Note that this was just over the temperature of boiling water ( 100°C , 212°F).This does not mean that CR benefits are due to just lower AGE's, rather that a doubling of AGE exposure can nullify the real benefits of CR. Also, rodents fed lower levels of exposure to AGE's in their food than normal chow - lived longer. At even higher temperatures of baking, broiling, and grilling - formation of these AGE cross linked molecules is much greater. AGE injury to our health is by inducing a rise in chronic inflammatory status. This elevated inflammatory status can nullify CR benefits that extend life span ! For Type-2-Diabetics (T2D), this AGE injury is even more devastating because T2D is a strongly inflammatory driven disease. This Step 2 action should be done at the same time as Steps 1 & 3. These together will greatly improve your health status. You will learn in the Diet Section of LHL to choose foods that minimize this NEEDLESS lessening of a LHL. The inflammation & Hot Cocoa or Cool Yogurt Anti-inflammation drink is available for down load (InflammationINFO&Cocoa/Yogurt Drink PDF . There are also more advanced methods to more rapidly remove AGE's and to remove a similar group of intracellular trapped crosslinked proteins, lipids, and carbohydrates called Lipofuscins (see AGEs & ALEs & LIPOFUSCIN REMOVAL PDF for SUBSCRIBERS ). These lipofusins accumulate in our various cells and can displace > 50% of cell volume with serious consequences to cell function. READ More about AGE's.
3. Ingest daily special long lived Antioxidant supplements and Adaptogens & slowly increase your Exercise level.
(See Antioxidants Special & Adaptogens.PDF for SUBSCRIBERS and the Exercise&Z's Section Chapter in the left Menu Section)
Like improving Glucose Handling, Lowering Chronic Inflammation, and lowering AGE intakes, this is a temporary lessening of the acceleration of this whole process - this is not curing the problem but buying us time to get to that without a faster physiological decline.). This Step 3 action should be done at the same time as Steps 1 & 2.
LEVEL 2 ( steps 4, 5, 6, 7, 8, &9) - fix underlying problems, improve stem cell function and muscle-brain feedback with Calorie Restriction & Exercise, remove heavy metal and organic toxins, yearly purge of 'abnormal' cells and also minimize parasite load, avoid needless foolish Darwin Awards, and mentally prepare or the consequences of a Longer Healthy Life
4. Correct the underlying Causes of Chronic Inflammation
(Each gradually developing age-associated disease has a different set of causes. For example, cardiovascular disease often starts with oxidation of circulating LDL lipid clusters that then stick to the artery wall where the immune system tries to clear away the damaged lipid cluster but just enlarges this problem with higher levels of local and systematic inflammation, Type-2-Diabetes elevation of blood glucose levels cause a cross linking of the sugar glucose to Hemoglobin as well as creating systematic inflammation. In each case we need to target the underlying inflammatory problem cause . See the CORRECTING UNDERLYING INFLAMMATORY CAUSES PDF for SUBSCRIBERS. These different problems have diverse sources and must be handled by more detailed information.
5. Improve Stem Cell Function and Maintenance of the Muscle-Brain Feed Back Loop to Rejuvenated Both by CR! CR turns out to not only extend life but it allows a much improved stem cell function as well as all the other life span extensions. Our brain and muscles are intimately linked by an newly discovered mutual feed back system that maintains and repairs muscle as well as stimulating brain connections and mental ability. To maintain this muscle-brain freed back loop you must be calorie restricted and exercise your muscles. There is no need for excessive workouts. Overdeveloped muscle building will mostly injure muscle tissue leading to stiffening fibrous collagen deposits. Additionally, body builders must eat high levels of protein almost constantly to gain muscle mass. They just want bigger muscles, but to get them they give up the fasting period that helps to turnover damaged proteins and recycle the useful amino acids. The oxidized amino acids are discarded. This fasting period forces each cell to preferentially chew up damaged proteins that in a well fed or over fed situation would not be broken up. A young man has about 10% oxidatively damaged cellular proteins while old men have some 50% oxidatively damaged proteins. This 50% creates unresponsive cells and impaired cell function. In addition to the exercise, you will need the daily period of fasting to prime stem cells and cause a turnover of damaged proteins and cellular garbage. This understanding of the benefits of CR and the muscle-brain feedback loops is critical to maintaining the healthy youthful status of both. This is a mutual feed back system is also critical to decreasing the build up of oxidized proteins Read MORE
6. Remove (Detoxify) Heavy Metal and Organic Poisons - Over the span of our life times we accumulate certain toxic heavy metals from living in a developed country and also ingestion in our food and water. This has been made worse by the scandalously unreported radioactive fall out from the Japanese Fukushima disaster. These heavy metals (except strontium-90) are easily removed by a simple paring of two nutritional foods that remove the heavy metals through the gut tube. Some persistent organic poisons and many more 'less persistent' organic toxins are also accumulated in our body . These heavy metals and organics can alter our epigenome (control of what proteins are built) by triggering the inflammation 'master switch' gene NFkB activation. Then the inflammatory cascade promotes epigenetic changes facilitating development of age-associated diseases AND then accelerates all the age-associated diseases that hasten our death. This is detailed in DETOXIFICATION OF HEAVY METALS & ORGANICS PDF for SUBSCRIBERS.
7. Conduct Yearly Abnormal and Cancer Cell Purges by the Parr Protocol (Cancer-Alternatives.pdf for SUBSCRIBERS ) and Yearly Bacterial/Parasite Purges to Ensure Minimal/Absent Parasite Burden (DETOXIFICATION & KILLING/CONTROLLING INTRA-CELLULAR PARASITES PDF for SUBSCRIBERS. While these may sound excessive, medicine has no ability to eliminate abnormal cells that are progressing toward cancer (save surgery as in hysterectomies, etc.). With the Parr Protocol, you either revert to non-dividing normal or just kill abnormal cells. This is done once a year for a period of two weeks with minimal effects on normal life, The Parr Protocol uses non-toxic food components that are our normal protections - only here at higher levels. In the same manner, while public health has largely succeeded at preventing horrendous plagues of infectious bacterial diseases, we have not been nearly so effective at other parasites. A combination of mycoplasma and other bacterial intracellular parasites as well as various single and multiple cell eucaryotic parasites still infest our species. Experts don't even have a good estimate of the number of people in the USA population that are infected by this profoundly inflammatory intracellular 'bacterial like' mycoplasma, but we are seeing connections to a variety of diseases. Other intracellular eucaryotic (nonbacterial) infection are estimated at 88% of the French population by the single celled eucaryotic parasite 'Toxoplasma gondii' (USA has estimated > 10%). Pinworms are estimated to infect some 10% of people in the USA. We can and should minimize these unwanted 'critters' . A large body of medical and scientific experts now believes these intracellular parasites and worms are causing a significant amount of disease. Inflammatory stimulation by these 'critters' adds on to the inflammatory AGE burden. Any needless sources of chronic inflammation that creates further pathology and shortens our lives need to be avoided or ended for a LHL. Read MORE
8. Lower Chance Events that can Profoundly Lower A Longer Healthy Life No stupid actions or ego driven Darwin awards please ! Ego should be in the service of a LHL (rational self interest), not a foolish demonstration of potentially dangerous folly. In the same way, long established habit may become life threatening when be do not reexamine what is occurring and how these habits fit into this. A classic example of this are the people who read this and understand that high temperature cooking caused food AGE's are prematurely ending our live's, but cannot bring themselves to give up such damaging behavior. Our whole life is a learning and readjustment process. Learn to have foresight and awareness and you will achieve a LHL. You can still have delight, but avoid the needless stupid dangers.
9. Mentally Prepare for the New Social, Political, Sexual and Psychological Changes that a Profoundly Longer Healthy Life will Bring. Marriage and reproduction will be a smaller proportion of our life spans. We need to become much more flexible in making new friends, dealing with new ideas, understandings, and adopting what is good.. This is especially so for the early pioneers of this new LHL who will lose old friends who did not believe this possible and died in the old stupid inflammatory disease driven way. We will need to construct a genuinely 'humane' human life, not one driven by the insanity of profit above the health of life on this earth. We are part of a larger Ecosystem, destroying that for short profit gain is not in our rational self interest. The current relentless rat race toward mostly meaningless goals under a equally meaningless 'hierarchal oppressive financial-political system' is dangerous for our species and the health of our earth.This is currently the system that turns all such as values and integrity into mere financial requirements that accelerate the rat race without adding to human joy or serenity. This is a system that does not encourage the the fullest development of each human for contribution to this human enterprise, and we must leave it behind. This also applies to the meaningless wars and oppressions occurring around the world. As you will see in the Ecology Section, the earth is bountiful an can be made much more so. What is occurring now is just further elaboration of the 'evil rich' arranging artificial scarcity, so they can accumulate more of the effort value of others. These too are a part of this desperate need to fleece or control others for exploitative advantage. Fundamentally an exploitative vision of human interaction. Our country was not imagined by our founders to be a relentless war state that uses the 'lies of terrorism' to 'create' terrorism at home and violence, occupation and destruction around the world. What is the point of a LHL if we are in a out of control, insane political war state? Come, my friends, there is a better way. Read MORE
WHAT WE CAN LEARN FROM ALL THIS: Our biological body is not so much failing us, rather we are abusing this biological body ! PRIMARILY, WITH COOKING CREATED AGEs in our FOOD and intake of toxins, heavy metals, etc. - and so hastening our own untimely end. At the same time, various un-addressed stealth parasites are wrecking havoc in a substantial portion of the human race - including the USA. In one form or another these processes are going on all over the planet in a way that limits our life span.
NEEDED HISTORICAL BACKGROUND
We need to have some background about what has limited our species longevity here-to-fore. Our species from our early history (some 200,000 years ago) all the way to 1900 AD died primarily of infections, with a lesser level of starvation, accidents, and human conflicts. Most premature deaths were due to needless infections that prevented a Longer Healthy Life. The gradual rise in life span of humans has largely been due to improvements in public health. These are:personal space not shared with infected others, clean water, sewage removal, quarantine of dangerous infectious individuals, removal of conditions that breed or support infectious agents, better food and healthy exercise,and a very modest benefit from vaccination and medical care. These processes excluded the very lethal bacterial, protist, and viral pathogens that claimed many lives. It did not, however, remove all potential pathogens. We routinely still get colds and flu as well as some other minor and some not so minor stealth diseases. In spite of these diseases, the average life span in the developed world has greatly expanded from as little as 200 years ago.
In the developed countries, we mostly die now of age associated diseases. These are cancer, cardiovascular disease, type 2 diabetes, dementia, autoimmune diseases, etc.. All of these are accelerated by an underlying gradual rise in chronic inflammation that promotes these age-associated diseases to curtail our life span. Remove the rise in chronic inflammation and and then the underlying causes and we will not have an acceleration of these diseases. Just as with the ending of infection as cause of our deaths, so too will we end the process of gradually rising inflammation that now accelerates the death of almost all of us. This is the next major expansion of a Longer Healthy Life for our species. It will come with prolonged mental and physical strength and a much more healthy aging process. This site is about how to bring that about for you NOW and what to do to gain yet further extensions of a Longer Healthy Life.
OVERVIEW OF CRITICAL FACTORS IN LONGEVITY
In order to have sufficient background about the over all picture of what leads to longevity, I have organized a figure below to show what aides and what can derail a Longer Healthy Life. Over almost all the history of our species, we have died of infections. Since we have better food and public health we now die of inflammatory diseases. We really must understand this before going to elaborate on the specific Levels. We would be as helpless as the 'Middle Age's victims of the Black Plague' if we let down our guard of Public Health.
Our long human effort to expand the human life span has been very successful as judged by the figure below.
Changing our focus from what we died from to what has extended our lives, we see in the above graph the history of human life span at different historical epochs. The vertical axis represents the percent of a cohort of humans remaining alive (all born the same year in a particular historical period). The horizontal axis shows the different human ages which they achieved. Some 50,000 years ago humans were mostly dead by age 20 with a rapidly declining graph that mimics typical deaths of wild animals. Europe of 15,000 years ago was much improved but still had not "rectangularized the curve" so that most humans lived a similar longer life span. By the time we get to the USA in the 1970, most humans get to some 70 years of life or more with a much broader survival of all humans (rectangularize curve). The dashed curves further out are the range we could achieve with the benefits of limiting calories to some 60% of what we would freely eat in the presence of abundant food (extrapolated from animal CR experiments). We already have experimental evidence that this works in primates like ourselves. See the pictures in the third slide upcoming slide of this introduction to LHL.net to see the difference this makes for 27 year old Rhesus monkeys (primates much like us).
In a similar way, we must avoid health damaging foods like the GMO disaster (Genetically Modified Organisms).There is always some level of chance in life, but our job is to minimize needless limitations on our Longevity. Below is a overview of what major inputs to longevity are needed.
Most humans who have lived to great age never planned nor took any care to maximize their longevity. All came from relatively long lived genetic stock, but their achievement was neither expected nor were many vices abstained from. Marie Calmut, the oldest documented human to live on this earth (122 years) smoked and drank till 100 years and then stopped while claiming that dark chocolate was keeping her alive (she might have been right !). Our studies of long lived Calorie Restricted animals (CR) have born fruit to allow us a Longer Healthy Life ( LHL ). Instead of this completely haphazard method, we now have good understanding of the 'how to' live a LHL, but to also massively increase the mental and physical health of this greater LHL. The schematic above is an overview of this process of increasing our LHL. We must understand the larger picture of what is required to come together for this LHL.
In order to understand the this process we can turn to the two shining examples of extension of human and animal life spans. These are the humans living over 100 years (centenarians) and animals subjected to Caloric Restriction.
Centenarians (Read More... ), living over 100 years, are both extremely rare and show almost no common behaviors like food types or even much similar genetics, besides usually coming from families that were generally long lived to begin with. Centenarians neither planed nor were extremely careful to act in a biologically wise age protecting manner. In short, the arrived at long life by the luck of genetics and chance. Most centenarians suffer from some or many age-associated diseases but not as much or as early as their shorter lived fellows. Despite their diversity, two fundamental processes are delayed and occur to lesser extent in centenarians. First, they retain better glucose handling by insulin in their bodies. Second, they have a slower and delayed rise in chronic inflammation.
Centenarians better glucose handling is accompanied by a lower ratio of mass to height (a variable called BMI or Body Mass Index , meaning that they are more slender than the average population. All of us can gain much of this better glucose handling by a choice what and how we intake carbohydrates in order to lower the burden on our pancreas insulin production and other hormonal systems. Minimal disturbance of these hormone interrelated glucose handling systems are fundamental in gaining a longer healthy life. Details of how to do this are covered in the DIET and DIET II sections of this site. Disturbance of this "good " glucose handing invariably also leads to higher inflammation rates and a much more rapid rise in overall chronic (abnormal ongoing) inflammation.
For an understanding of the declines in age in human beings, see: Read more...
A lower level and delayed development of increases in chronic (constantly ongoing) inflammation is the second important shared characteristic of all centenarians. A consequence of this lower and slower rise in inflammation is the lower and slower rise in age-associated diseases.
When we look at the experimental evidence for the most profound life extensions ever found for mammals, we are looking at calorie restriction (Read more.. COMING SOON). What extends life by this simple limitation of calories with sufficient proteins and required lipids, vitamins, and minerals ? It turns out that it is the same characteristics seen in Centenarians (good glucose handling, low inflammation ). CR animals do these more powerfully. For a long time the free radical theory of aging focused on the formation of these highly reactive unpaired electron molecules (free radicals) that react to damage other biological molecules. Despite this long period of dominance of the "free radical theory of aging", no amount of supplemental (exogenous) antioxidants nor even genetic augmentation of the level of endogenous (body produced) antioxidants has led to across the board extensions of life. Free radicals are problems and they are dangerous when they rise above the levels the body uses for information as a feed back system.
If inflammation is accelerating our age-associated disease death, where dose this inflammation come from?
# 4 Sources of Chronic Inflammatory Elevation and Actions to End
Please note that all of these trigger the NFkB gene activation and subsequent production of inflammatory cytokines. All physiological insults to body trigger this mechanism. Many pathogens have also learned to use the inflammatory process to aid their survival and further multiplication.
Heavy metal contamination
It is widely understood in science
that toxic heavy metals lead to activation of NFkB activation and production
of inflammatory cytokines that can produce
a chronic inflammation problem.You
must get rid of these by detoxification, if you have silver filings,
you have slowly leached out mercury (Hg) that is extremely toxic and
thereby inflammatory. Toxic heavy metals
lead to the activation of NFkB production of inflammatory cytokines.
Toxic heavy metals should best be removed by two diet components that
trap these in the gut tube and are evacuated as feces. This lowers the
burden on the kidneys. See DETOXIFICATION
OF HEAVY METALS & ORGANICS PDF
Elevated blood homocysteine levels Homocysteine is a intermediate amino acid between methionine and cysteine. Both Methionine and Cysteine are put in proteins, but homosysteine is not. Homocysteine is a danger to all long lived proteins because the thiol gorup (SH) damages structure and irreversibly damages the functions of various enzymes and long term structural proteins that ensure proper action of the blood vessels. This also leads to a profound inflammation that can feed back to yet more damage and possible autoimmune reactions to altered proteins. Long periods of high exercise exertion (over a hour) elevate homocysteine levels out of the normal range, as does high consumption of alcohol. High homocysteine levels leads to constriction of blood flow and occlusion of blood vessels. Once we have high homocysteine levels, only the stroke aspect is diminished, not the artery disease consequences. We must take enough Vitamins B6 (Pyridoxine), Folate B9s, and Vitamin B12 (cobaltamine) to ensure we avoid this problem. This is one of the reasons that I urge peole to take S-100 stress level of time released B vitaimins in the Supplement Section. Timethylglycine can also be protective here, but take the higher B6,B9, & B12 Vitamins as well.
Smoking - Smoking damage like other physiological insults is found to be mediated by NFkB activation. NFkB is the 'master switch' for inflammation and leads in these pathological cases to high levels of inflammatory cytokines that accelerate age-associated diseases., This NFkB activation by pathological physiological insults is likely also the master switch for the process of epigenetic (changes in expression, not damage to DNA) that can directly lead to a pre-cancer and then cancer, as well as other age-associated diseases. Which one is likely dependent on genetics and environmental exposures over the life time.
In order to decrease or mostly eliminate the source of our chronic inflammatory problems we must get some idea of the source(s) of them. Intake of AGE & ALE cross-linked molecules is common due to our cooking of foods, with higher temperatures generating higher levels of these AGE & ALE molecules. The classic genesis of arteriosclerosis and heart disease is oxidized LDL's (Low Density Lipoproteins) that are due to insufficient antioxidant protection, that then become inflammation related artery plaques that begin the process of occluding arteries. Obesity in the absence of type-2-diabetes can elevate inflammatory cytokine production. Elevated glucose levels leading to type-2-diabetes are certain to elevate inflammation by multiple mechanisms. Over 50% of the people over 50 year of life have a gum inflammation by bacteria (gingivitis) situation that can leach highly inflammatory bacterial lipopolysaccharides into the blood stream were they will incite highly inflammatory consequences. Many if not most have some level of heavy metal contamination or drug/organic chemical exposures that need be detoxified by removal. Chronic infection with bacteria or viruses (or parasites) always leads to a chronic elevation of inflammation. Even misfolded cell surface proteins (B-amyloid proteins in Alzheimer's disease) are a focal source of inflammation.
Evaluating which of these applies to you is something that should be considered with a physicians guidance. Read more... COMING SOON
After you have greatly reduced the underlying sources of your inflammatory problems and improved both insulin sensitivity and lower the stress you place on your pancreas, then you can go on to a level of rejuvenation. This instead entails a simple treatment that corrects the problems underlying the age-associated diseases and preserves your muscle and Brain functions with age.
Remember the long lived Calorie Restricted (CR) animals that like the human Centenarians showed superior insulin sensitivity and glucose control along with lower inflammatory status? They have also taught us something very profound about maintaining muscle and brain ability.The CR animals have only minor mental loses with age and do a much better job of keeping their muscles in good state, despite little exercise. Both of these last two are profoundly lost in older humans who seem to waste away muscle and lose brain sharpness and ability. Fasting CR animals are able to retire damaged proteins back to amino acids that are reused, and replace damaged or dead cells with 'stem cells'. Stem cells are uncommitted cells that can replace damaged or dead cells in various organs - something that we could do all our lifetime if we did not gradually lose the ability to activate these repair and rejuvenation stem cells. The secret is simple, both turnover of damaged proteins, mitochondria, and stem cell recruitment and repair/replacement of damaged organs (including the brain and muscles) REQUIRES a process of daily fasting to be optimized. This process of fasting leads to a turnover of oxidized (damaged) protein, of damaged mitochondria, and recruitment of stem cells to repair and rejuvenate various organs. There is a profound brain-muscle feedback loop that is maintained and strengthened by the intermittent fasting READ More... COMING SOON
Over the human life span there is a gradual rise in the percent of cellular proteins that are oxidized. A 20 year old man will have only 10% of his cellular protein oxidatively damaged, while a 70 year old man will have about 50%. This 50% oxidized is a very serious impediment to cell function. The same is true of damaged mitochondria. Stem cell recruitment and replacement of damaged or dead cells in an organ depends on this low level of nutrients as a required process of recruiting stem cells. So, now you know part of the process of repair and rejuvenation of our tissues with age, but it requires a fasting process to be maintained in later years. This process is even more augmented by fasting and exercising when fasted. The payoff here is better maintenance of our tissues and the proper interaction of various systems in a cooperative fashion. In particular, it means that mental abilities can be retained and physical strength can also be retained. It is very probably that all organ functions are benefited by this same process because it results in reconstitution and rejuvenation of organ function. Forget the nonsense of resveratrol and pterostilbene 'replacing' calorie restriction, they don't do the fasting that is needed to turnover damaged proteins and organelles as well as recruit stem cells for repair & rejuvenation. Now we can more profoundly understand why CR animals can live 20-40% longer than the ad libitum (as much as you want) matched pairs. CR results in profound improvements in insulin sensitivity that translate into lower insulin and glucose levels, profoundly lower and delayed rise in chronic inflammation with age, the fasting process results in turnover of oxidatively damaged proteins that leads to new "good" proteins and mitochondria, while the same fasting process recruits stem cells to repair and rejuvenates not only muscles and brain but all organs. This combined effect cannot be achieved by such stupid interventions as supplemental or induced endogenous growth hormone (GH) that does create more muscle while decreasing body fat, but ignores this fundamental need to recruit new stem cells for repair and rejuvenation of all organs and tissues as well as turnover of damaged proteins to avoid a buildup of damaged ineffective proteins. The use of supplemental or augmented endogenous GH will not extend to a Longer Healthy Life, but may 'short term' satisfy the vanity of some confidence needful males for better muscles. Read more... COMING SOON
Another problem with living on this earth is that we are exposed to various heavy metal poisons and even mores so organic and drug toxins. While some of these are naturally eliminated by our bodies detoxification system, some are long retained in the ecosystem to be an ongoing threat (often called 'persistent'). We can remove long retained heavy metal toxins in a safe way that does not go through the vulnerable kidney, but uses the intestinal tract instead. We can also slowly remove dangerous organic poisons with a modified citrus pectin. Thus we have safe ways to detoxify our body from it's long accumulation of organic toxins, drugs, and heavy metals.
Over the course of our lives we are inadvertently exposed to a very wide variety of dangerous toxic heavy metals that take up permanent residence to continue to injure us. At the same time, we are bombarded by various drug and organic poisons in our food , water, air, and our home and work exposure. This includes herbicides and pesticides (that are almost all 'epigenetic poisons') as well as the huge untested number of organic chemicals released without proper long term testing for generational damage. The USA is a great big uncontrolled experiment in dangerous toxin exposure due to ingestion of GMO DNA that takes up residence in our gut bacteria and then produced toxic pesticides in our own gut. This is almost as bad as our exposure to radiation principally due to the insanity of nuclear power plants that are now seen by most intelligent people as a horrible greed driven human disaster that is likely to deeply damage our genes and the future of our children.
While we cannot get rid of these dangerous GMO plasmids in our gut bacteria without some sort of antibiotic purge, we can remove the heavy metals (including such radioactive ones as 239 Plutonium an Uranium) and similarly remove most organic (drug and pesticide/herbicide) poisons that we have unknowingly been exposed to.
While we are on the subject of detoxification, we can also remove almost any parasites, unhealthy bacteria, yeast, protists, and the like of unwanted and dangerous (biological) living organisms. While we can inactivate blood stream floating viruses, we cannot easily get rid of viruses that integrated into our cellular DNA in the nucleus of the cell (HIV, cold Viruses, etc.). Along the same lines, we do have simple non-toxic methods to protect ourselves in the event of biowar or epidemics ! See IMMUNE ENHANCEMENT PDF for SUBSCRIBERS Read more... about surviving biowar. COMING SOON
When we cook food, we inadvertently cause inappropriate cross linking of reducing sugars (glucose, fructose, etc.) with proteins and unsaturated fatty acids. These biologically inappropriate products are called AGEs (Advanced Glycation Endproducts) and ALEs (Advanced Lipid(glycation) Endproducts). These are molecules that our body does not do a good job or detoxifying. Worse yet, a vascular located receptor called the RAGE receptor responds to the presence of these molecules in our blood as if they were products of some invading organism. This triggers massive whole body inflammation that then causes problems we have already detailed.
The higher the temperature at which we cook food, the worse this inflammation is. We can minimize this process for foods that need be cooked (fish like Salmon, eggs, and all other meats) by keeping cooking temperatures no higher than boiling water. We still get AGEs and ALEs but orders of magnitude (powers of ten) less that when we barbecue, broil, roast, etc. This also applies to the treatment of our carbohydrates that typically contain both reducing sugars and both protein and unsaturated fatty acids. When we heat these to baking temperatures, these reactions occur and generate AGEs and ALEs. Foods that might at first seem to be kept cool (oils,butter, cream, etc) are also massive contributors to our AGE and ALE levels because of food industry 'flash temperature processing' that trigger the same process.
If you imagine this contribution to the inflammation ACCELERATION of our death is minor, you are greatly mistaken. When calorie restricted animals are compared to normal eat as much as you wish (ad libitum), the CR animals get some 20-40% increase in maximum life span over the ad libitum. If you just heat the CR animals food (not that of the ad libitum controls) to temperatures that are well below below boiling, the CR process of additional life span is completely ended relative to normal (unheated ) food for the ad libitum. This is a profound loss of 20-40% extensions of healthy life spans. Imagine what you are doing to yourself with barbecue, broiled, and roasted/baked foods that are at heated to much higher than the boiling point of water.
It is peculiar that the very quality of being able to keep meat around longer by cooking it (sterilizing) that allowed us to support our very active brains with high protein levels (5% of mass but uses some 20% of our energy) is now turning up to limit our life span by inflammation. Such is the irony of life. We need to find alternatives to cooking our food as this is now limiting us via this inflammatory process - even if we are otherwise healthy and trim.
Changing this dangerous atavistic burning of our food to produce shortened life spans can be corrected without loss of taste or delight in food. Read more...
Cancer is always a risk for a multi-cellular organism. We can minimize this risk by acting to destroy altered or transformed cells that are developing toward cancer. The simple and without risk protocol for ATTACKING Cancer Unique Vulnerabilities 1-3 described in the Cancer-AlternativesMiniPreview.pdf for SUBSCRIBERS allows you to revert to harmless non-dividing cells or kill cancer cells. I routinely do this once or twice a year for a few weeks. This process is probably the principal way your body destroys not only cancer but abnormal cells that are progressing toward cancer but not yet there. Our current problems with the insanity of nuclear power plants (or nuclear weapons) entail massive risk because a 1 microgram speck of 239 Plutonium ( 0.000000035 ounce - not even visible to the eye) when inhaled will most likely result in lung cancer 5-20 years later. The only way to fix this is to revert damaged cells to non-dividing (terminal differentiated) cells or kill these abnormal cells. Read more...
The longer we live, the greater the likelihood of "chance events" being responsible for our demise. A fall that brakes bones, a minor cold that gets worse and worse, and many other major or minor events can injure or end our lives. What is very good news about the materials covered here is that one will massively put off the period of feebleness and fragile health status. This is because we will have maintained our stem cell repair and rejuvenation function and avoided the typical profound loss of glucose handling with age as well as the completely needless rise of inflammation with age that largely diminishes our ability to conduct good maintenance of our body. I am betting on the basis of extended life span and delayed rise in age-associated diseases of the CR animals, that this will do exactly the same for us - ONLY WE CAN DO YET BETTER. We still do not know how much of a Longer Healthy Life this will give us, but it is clear that these are the first steps. At the same time we must use our accumulated wisdom to avoid foolish 'Darwin awards'. Most of these behaviors are about vain or foolish actions that can easily be easily avoided by some mature judgment. Read more... COMING SOON
While human extended families have been common in human history, there was never a time when potentially 4 or 5 generations of the same family were alive. This is the likely consequence of extending the human life span by ending much of the current needless inflammatory limitations. This will bring other major changes related to expectations of single long term marriage partners for life and the full set of complications of a very large net of family relations. Read more... COMING SOON
Another gene involved in our process of aging is the TOR or mTOR (mammalian TOR) gene. Partial inhibition the TOR gene leads to increases in life spans that are very large in lower animals but more modest in mammals. Read MORE...
Absent infections and unfortunate genetic disease, WHY DO WE AGE? Why don't we just go along without an aging process?
What we have learned in this section is that too rapid and too high a delivery of nutritional support drives "over stimulation" of the Insulin/IGF-1 and mTOR control systems along with the ensuing disease creating and accelerating chronic inflammation that appears to be able to stimulate harmful epigenetic charges that set up and generate conditions for the various age-associated diseases. Thus, this nutritional excess "over stimulation" of the Insulin/IGF-1 & mTOR control systems are the principal causes, and set the rate of our human and general mammalian aging (absent infections, etc.). this combines with genetic and environmental influences to select which of the of age associated diseases develops first as well as setting the timing of onset and rate of development of these diseases. Extending the healthy period of life involves slow nutritional delivery of just enough nutrition to blunt the elevations of Insulin-IGF-1 and mTOR along with lessening the development of a rise in chronic inflammation.
Read MORE PUTTING IT ALL TOGETHER
We can lower the elevation of the Insulin/IGF-1 axis, mTOR gene, and the ensuing rising chronic inflammatory sequence in humans by food components in our historic diet that have been used by humans for thousands of years ! Other specific components of our normal diet are able to rapidly undo the epigenetic changes created by this elevation sequence of unwise actions. See Longevity PDF for SUBSCRIBERS.